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KMID : 0370219970410040498
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Yakhak Hoeji
1997 Volume.41 No. 4 p.498 ~ p.511
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Effects of UK 14 , 304 , An α2-Adrenergic Agonist , on Renal Function in Dog
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고석태/Ko ST
김해석/최홍석/Kim HS/Choi HS
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Abstract
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The effects of UK 14,304, an alpha2-adrenergic agonist, on renal function were investigated in dogs. UK 14,304, when given intravenousely(15.0mcg/kg, 50mcg/kg), produ ced the increase of urine flow accompanied with the marked augmentation of free water clearance (CH2O) and reabsorption rates of sodium in renal tubules (RNa), and the remarkable decrease of osmolar clearance (Cosm) and the amounts of sodium excreted in urine (ENa). UK 14,304 given into a renal artery(l.5mcg/kg, 5.0mcg/kg) elicited the increase of urine flow with the augmentation of CH2O in both kidney. UK 14,304, when administered into carotid artery(3.0mcg/kg, 10.0mcg/kg). exhibited the same aspect as shown in intravenous UK 14.304 at smaller dose than the intravenous dose. Diuretic action of intravenous UK 14,304 were produced together with increase of CH2O in situation of water diuresis too, changes of renal function in this state were the increase of Cosm, ENa, and EK (excreted amounts of potassium in urine), and the decrease of RNa and RK, these were different appearances from situation of saline diuresis. Diuretic action of intravenous UK 14,304 were blocked completely by post or pretreatment of yohim-bine, alpha2-adrenergic blocking agents, and inhibited by pretreatment of vasopressin, antidiuretic hormone. Above results suggest that UK 14,304 produces the diuretic action by the inhibition of vasopressin secretion and suppression of electrolytes reabsorption of electrolytes in renal tubules mediated with central alpha2-adrenoceptor in dog.
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